The Anaconda is a villain only appears in a one episode, "Huge Python". He was a cyborg mobster. Numbuh 4 put him in the tree branches before died because he got eaten by a giant python. His final words is "Help! NOOOOOO!" He was voiced by a Tom Kenny.
- He has a red hair, one green eye, one red eye, robotic neck, robotic arm, robotic leg and wears green fedora, red necktie, blue coat, green trench coat, red pants, boots and shirt.